"He's coming along well and he drew wide, went back to last and then circled them. He was the winner and then he peaked last time.
"A different one wins these types of three-year-old races every week, so we might as well give it a go."
Buthelezi has drawn barrier 13 and was rated a $17 chance after the final field was declared on Tuesday.
Chris Waller, who notched up his 200th Group 1 win when Birdman took out the Doomben Cup last Saturday, is chasing a third Queensland Derby success in the past six year.
Waller has four runners safely in the field – Kilman (barrier three), Providence (eight), Monopolistic (17) and Defendant (11) - along with fifth emergency Eynesbury (21).
Moody and Coleman have a strong hand in the other Group 1 feature at Eagle Farm on Saturday with Desert Lightning lining up in the Kingsford Smith Cup.
Desert Lightning, who made a name for himself as a middle-distance horse in New Zealand, has been transformed into a sprinter under Moody and Coleman's care.